Bing Center Clinic

Clinical Trials

Clinical Trials

The Bing Center for Waldenstrom's Research at the Dana-Farber Cancer Institute is committed to providing comprehensive state-of-the-art treatment for Waldenstrom's Macroglobulinemia, including novel therapeutics, combination therapies, and immunotherapies. Our clinical trials are devoted to advancing the effectiveness of current treatment options for Waldenstrom's, while ensuring the highest standard of care.

One of our priorities is maintaining active clinical trials year round in an effort to constantly improve our understanding and continue to offer patients the most effective treatments for Waldenstrom's macroglobulinemia. All of our clinical trials are open through the Waldenstrom's Macroglobulinemia Clinical Trials Group [http://www.wmctg.org/], which is composed of over 20 major cancer centers around the world. By maintaining such an extensive contingent of collaborating centers, we hope to be better able to enroll patients in our trials without delay. Not only does the WMCTG allow more convenient patient access to treatment, but will also facilitate completion of clinical trials in a more timely manner.

New clinical trials are initiated only after drugs and other active agents are carefully screened through basic research studies and/or other successful experiences in other patient populations. The goals of all our clinical trials include increasing the number of patients entering into remissions, particularly complete remissions, as well as increasing the duration of these remissions.

All of our proposed clinical trials are approved by a Scientific Review Committee (SRC) and an Institutional Review Board (IRB) and are regulated through the Office For The Protection Of Research Subjects (OPRS) at the Dana-Farber Cancer Institute. The IRB serves to ensure that our trials comply with existing regulations of the FDA, Department of Health and Human Services (HHS) and the state's DPH for the protection of human subjects.

If you are interested in more information about a clinical trial or becoming a co-investigator on one of our trials, please contact Kirsten Meid at 617-632-5598.

For questions about any of our clinical trials, please call 877-DF-TRIAL (877-338-7425).

Recently completed (ongoing, but not recruiting participants)

A Study of Daratumumab in Patients With Relapsed or Refractory Waldenström Macroglobulinemia

A Study of Ulocuplumab And Ibrutinib in Symptomatic Patients With Mutated CXCR4 Waldenstrom's Macroglobulinemia

A Study Comparing BGB-3111 and Ibrutinib in Subjects With Waldenström's Macroglobulinemia (WM)

Phase II study on venetoclax in Waldenstrom macroglobulinemia with prior exposure to BTK inhibitors

Ongoing (recruiting participants)

Mavorixafor in Combination With Ibrutinib in Participants With Waldenstrom's Macroglobulinemia (WM) Whose Tumors Express Mutations in MYD88 and CXCR4

Phase II study on ibrutinib and venetoclax in previously untreated patients with Waldenstrom macroglobulinemia

Pilot study on Dasatinib In Waldenström Macroglobulinemia

A Study of Oral LOXO-305 in Patients With Previously Treated CLL/SLL or NHL